Concerning treaties, Article 6 states: This Constitution, and the Laws of the United States which shall be made in Pursuance thereof; and all Treaties made, or which shall be made, under the Authority of the United States, shall be the supreme Law of the Land; and the Judges in every State shall be bound thereby, any Thing in the Constitution or Laws of any State to the Contrary notwithstanding.
I have to quibble on the point of Regulating commerce not being the equivalent to Prohibiting commerce, since we already have the legal and political precedent of the enactment and repeal of a specifically enumerated Prohibition amendment. In other words, according to the legal precedent established by our own Constitution, Prohibition is not a form of Regulation.
Where, in our Constitution is there any specifically enumerated power to Prohibit interstate commerce? Why does the legal precedent of the repeal of the prohibition amendment not have standing as a repeal of a power to prohibit forms of interstate commerce?
I have read that any unconstitutional is null and void, and need not be followed as a matter of states' rights.
Your view still does not account for federal interference in intrastate commerce concerning drugs if not on federal property.